Sunday, 5 June 2016

Recorded presentations from the Southern California Genealogical Society's Jamboree 2016

The Southern California Genealogical Society's Jamboree took place this weekend. Some of my friends in America were attending and I've been keeping up with their posts on Facebook and Twitter. A number of the sessions were livestreamed around the world, including six sessions from Genetic Genealogy 2016, which was a special day dedicated to DNA testing with a number of parallel streams of talks.

If you were not able to watch the livestreamed sessions you can catch up with them in the online archive so long as you have registered for a free account. Registration details can be found on the Jamboree blog.

The DNA Day presentations are pay to view. You can either pay $99 to watch all six sessions or watch individual sessions at $20 a time. If you sign up for the full package you also have access to the "syllabus" which is the programme for the day and includes all the handouts from the talks. The programme is well worth a read in its own right. The archive of the DNA talks is online until 5th July. For full details see the blog post on the Jamboree blog Jamboree 2016: Miss the Genetic Genealogy 2016 Conference? We've got you covered!

If you've been following the debates in the genetic genealogy community about triangulation and DNA Circles I highly recommend watching the talk by Diahan Southard on "Circles or Triangles? What Shape Is Your DNA?"

I also enjoyed watching Blaine Bettinger's review of genetic genealogy events from the past year and a half. This is an incredibly fast-moving field and it is challenging at the best of times to keep up with all the latest developments, but Blaine did a good job reviewing some of the more important changes from the big three testing companies and the phenomenal growth in the size of the company databases.

Audio recordings of other presentations from the conference, including all the other DNA sessions, can be purchased individually for a fee from the Conference Resource website. Some of the presenters have offered to share their slides online so I will update this blog post with links as they become available.

If you want to get a flavour of the event Randy Seaver has compiled a compendium of blog posts from Jamboree.


Further reading

Tuesday, 24 May 2016

New match thresholds for Family Tree DNA's Family Finder test

As a "trusted blogger" I have been given advanced notice by Family Tree DNA of forthcoming changes to the match thresholds for the Family Finder autosomal DNA test. The changes are to be rolled out very soon once the final quality control checks have been run. An e-mail will be sent out to project administrators in due course. Here are the details I received from Family Tree DNA:
For several years the genetic genealogy community has asked for adjustments to the matching thresholds in the Family Finder autosomal test. After months of research and testing, we will shortly be implementing some exciting changes.

The current matching thresholds – the minimum amount of shared DNA required for two people to show as a match are:

● Minimum longest block of at least 7.69 cM for 99% of testers, 5.5 cM for the other one percent

● Minimum 20 total shared centiMorgans 
Some people believed those thresholds to be too restrictive, and through the years requested changes that would loosen those restrictions.

The following changes will be made to the matching programme.

● No minimum shared centiMorgans, but if the cM total is less than 20, at least one segment must be 9 cM or longer.

● If the longest block of shared DNA is greater than 9 cM, the match will show regardless of total shared cM or the number of matching segments.

The entire existing database will be rerun using the new matching criteria, and all new matches will be calculated with the new thresholds.

Most people will see only minor changes in their matches, mostly in the speculative range. They may lose some matches but gain others.
This is very welcome news. This was a change that many of us had asked for and it's good to know that Family Tree DNA have listened to us.

When setting a cut-off limit it is always difficult to get the balance right between false positive and false negative matches but the previous 20 cM threshold was problematic because all segments right down to 1 cM were included in the total. Family Tree DNA do not currently phase their data before assigning matches (sort the alleles into the maternal and paternal chromosomes) and we know that the vast majority of unphased small segments, particularly under 7 cMs, are false positives.(1) Some people were therefore declared as matches when most of the segments they shared were small pseudosegments, and they were unlikely to share a recent common ancestor. In contrast, some legitimate cousin matches were not showing up because they fell just below the threshold. Under the old system two cousins could potentially share a 15 cM segment but not have enough of the small pseudosegments to make up the 20 cM quota. Anecdotally it has been observed that the 20 cM threshold was a particular problem for people with African ancestry who tend to have fewer of these false coincidental matches on small segments.

Some people were advocating for Family Tree DNA to set the threshold at 7 cMs, but the 9 cM threshold is a sensible compromise. There is still a high false positive rate for unphased 7-9 cM segments, so this will ensure that the reported matches are more likely to be real.

It should also be remembered that, in the vast majority of cases, if you match on a single segment under 10 cMs you will not share a common ancestor within the last ten generations. Even matches of 10 cMs can be very distant.(2) One study found that fewer than 35% of IBD (identical by descent) matches of 10 cMs fall within the last ten generations, and over 30% of segments of this size date back over 20 generations.(3)

I've also noticed in my own data that a lot of the segments in the 7 to 9 cM range seem to fall into large triangulated groups. If these segments are real then this is an indication that they are in what are known as pile up regions. These are regions of the genome where lots of people match because they share the same ethnicity or for some other reason rather than because they share a single recent common ancestor.

Indeed, because of the difficulties in working with unphased segments under 10 cMs many genetic genealogists recommend focusing only on matches who share 10 cMs or more.

I hope to do a comparison of my before and after matches at Family Tree DNA and will be interested to see comparisons from other people, but this is a very welcome and positive change. Thank you Family Tree DNA!

It was not clear from the original announcement but it has now been confirmed that all matches with a total cM count of 20 cMs with a longest segment of 7.69 cMs or more in size will still be reported. Blaine Bettinger has provided a very useful decision tree to clarify the situation in his blog post Family Tree DNA updates matching thresholds. It therefore seems unlikely that many people will lose matches. Note that FTDNA does include all small segments right down to 1 cMs in their match thresholds. Most of these smaller segments, and especially those under 5 cMs are just noise and are best ignored unless you are able to do phasing and very careful chromosome mapping by testing a large number of close family members and known cousins.

Update 25 May 2016
I have received further information about the forthcoming update in an e-mail sent out by Family Tree DNA to all their volunteer group administrators. Here is the relevant section:
We also slightly altered other proprietary portions of the matching algorithm that will, to a small degree, affect block sizes and total shared centiMorgans. These changes should have only marginal effects, if any, on relationships, generally in the distant to remote ranges. 
There’s a separate proprietary formula that is also applied to those with Ashkenazi heritage, but you can, of course, expect to have more new matches than those not of Ashkenazi heritage. 
Please keep in mind this change will not affect close matches, only distant and speculative ones. Some matches will fall off, others will be added. Most people will likely have a net gain of matches. 
Your myOrigins results may change slightly with the rerun, but we have not updated or changed myOrigins yet. We’ll let you know when that happens.

See also

1. See the statistics on false positive matches on the ISOGG Wiki page on identical by descent.
2. See the blog post by Steve Mount on Genetic genealogy and the single segmentOn Genetics, 19 February 2011.
3. See Figure 2 in the paper by Doug Speed and David Balding on Relatedness in the post-genomic era: is is still useful? Nature Reviews Genetics 2015 6: 33-44. 

Tuesday, 17 May 2016

AncestryDNA are to use a new chip for their autosomal DNA test

AncestryDNA have announced that with effect from this week they will be using a new chip for their autosomal DNA test. The announcement was made in a blog post by the Ancestry team Customer testing begins on new AncestryDNA chip published on 12th May.

Some genetic genealogists in the US were invited to attend a conference call with the AncestryDNA team where they were given the chance to ask questions about the changes. For further details read the following two articles:
I will update this list if any further articles are published.

Monday, 16 May 2016

Rebranding of BritainsDNA and ScotlandsDNA as MyDNA Global

There appear to be changes afoot at BritainsDNA and ScotlandsDNA following their acquisition by Source BioScience in December 2015.

If you visit the websites of BritainsDNA, ScotlandsDNA and the other associated websites (IrelandsDNA, CymruDNAWales, YorkshiresDNA, IzzardsDNA) you are now greeted with an error message. Here's the message as it appears in Google Chrome after clicking on the Advanced button. 
Here's the message as it appears in Firefox.
If you disregard the warnings and proceed to the websites then they are still functioning as normal. The security certificate mentions a company called MyDNA Global. I took a look at their website and it is a direct copy of the BritainsDNA family of websites but with a new name.

It therefore looks as though Source BioScience, the new owners, are in the process of rebranding the various BritainsDNA websites. There is also a newly created MyDNA Global Facebook page and Twitter account.

There is no change in the product offerings but the websites have been pared down. There is no longer a list of employees and the events page has disappeared. The legal verbiage on all the sites now appears in the name of MyDNA Global.

I've spoken to a couple of people who have tested at BritainsDNA but so far no one has had any communication from the company informing them of the changes.

Source BioScience have now published their annual report for the year ending on 31 December 2015. which provides further information about the acquisition. Here is a quote from page 17:
In December the Group acquired BritainsDNA, a provider of DNA-based ancestry and genealogy products to the consumer market. Source BioScience has been providing the laboratory testing and analysis for BritainsDNA for a number of years. The acquisition will deliver incremental revenue and increased operational efficiency for this business. The commercial activities will be migrated across to the Group’s e-commerce platform and e-Shop early in 2016.
The financial details of the acquisition are given on page 77. It would appear that the Moffat Partnership, the parent company of BritainsDNA (now renamed as Source BioScience Scotland) had considerable financial liabilities amounting to £570,000 but little in the way of tangible and intangible assets. These liabilities appear to have been offset by a goodwill valuation of £584,000.

There have not been any announcements from Source BioScience about their future plans for BritainsDNA/MyDNA Global so it will be interesting to see what happens in the coming months. If anyone has any further information do let me know.